Extensive antimicrobial resistance and plasmid-carrying resistance genes in mcr-1-positive E. coli sampled in swine, in Guangxi, South China

Abstract Background The discovery of the superbug mcr-1 -positive Escherichia coli (MCRPEC) has drew greet attention. Swine-origin multi-drug resistant MCRPEC been a potential threat to public health and safety. However, there were few detailed studies have reported on swine in Guangxi, South China. Results In this study, thirty-three strains detected from 142 E. 116 samples Guangxi 2018. Which could be classified into eight unique STs total six incompatibility plasmid groups (IncFI, IncHI1, IncY, IncN, IncI1 IncX1). After that, susceptibility isolates 27 antimicrobial agents belonging 17 categories was tested. There nineteen 3rd 4th generation cephalosporins twelve carbapenem resistan. Importantly, showed high resistance highly for imipenem meropenem, which forbidden use livestock production. Three further proved extensively drug-resistant (XDR), other multi-drug-resistant (MDR). Furthermore, we found that plasmid-carrying genes coexisted with gene isolates. listed as follows: ?-lactamase e.g. ESBL ( bla CTX-M14 , CTX-M24 CTX-M123 OXA-1 ), plasmid-mediated AmpC (pAmpC) CMY-2 NDM-5 non-?-lactamase qnrA qnrB qnrS aac (6?)-Ib-cr tetA tetB sul1 sul2 floR aadA ). Conclusion Thirty-three displayed wide profile resistance. Plasmid-carrying might main cause multidrug This study highlighted necessity long-term surveillance pigs.